James CookRB | Bills

James Cook Viewed As An RB2 Against San FranciscoNovember 29, 2024 | 09:15 PM

Buffalo Bills running back James Cook projects to see plenty of usage on Sunday night against the San Francisco 49ers. The 49ers are fairly weak against fantasy football running backs this season, allowing the 10th-most points per game. Most recently, Josh Jacobs ran for 106 yards and three touchdowns against them. Cook can beat defenses on the ground or through the passing game. With the potential for hazardous weather in Buffalo, Cook may hear his name called more often. He's ranked as a high-end RB2 in Week 13.